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ESM3
EvolutionaryScale
Structures found in this family (2)
Linear Direction
,
Linear Separability
By model (2)
ESM3 (98B, LARGE)
· 98B
Linear Direction
,
Linear Separability
ESM3 (1.4B, OPEN)
· 1.4B
Linear Direction
,
Linear Separability
Observations (2)
A dominant unsupervised PCA axis in real ESM protein language models orders sequences along a cellular-to-viral nativeness continuum
A protein-LM nativeness axis orders sequences; viral signal stays separable
Papers
Viral Proteins Reveal Geometry of Protein Language Models (2026)